Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis.

A new class of topical receptor-selective acetylenic retinoids, the first of which is tazarotene, has been developed.
Our purpose was to compare the safety, efficacy, and duration of therapeutic effect of 12 weeks of once-daily tazarotene 0.1% and 0.05% gel with that of twice-daily fluocinonide 0.05% cream in the treatment of patients with plaque psoriasis.
Three hundred forty-eight patients with plaque psoriasis were enrolled and 275 patients completed a multicenter, investigator-masked, randomized, parallel-group clinical trial.
Both tazarotene gels were as effective as fluocinonide in reducing plaque elevation after 1 week of treatment, and tazarotene 0.1% gel was similar to fluocinonide in reducing scaling of trunk/limb lesions at all study weeks except week 4. Tazarotene 0. 1% gel was similar to fluocinonide in reducing scaling of knee/elbow lesions at weeks 8 and 12. Fluocinonide had a significantly greater effect on erythema than tazarotene at weeks 2 through 8. However, treatments were not significantly different at week 12, and tazarotene demonstrated significantly better maintenance of therapeutic effect after cessation of therapy.
Tazarotene 0.1% and 0.05% gels were safe and effective in the treatment of mild-to-moderate plaque psoriasis.
AuthorsM Lebwohl, E Ast, J P Callen, S I Cullen, S R Hong, C L Kulp-Shorten, N J Lowe, T J Phillips, T Rosen, D I Wolf, J M Quell, J Sefton, J C Lue, J R Gibson, R A Chandraratna
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 38 Issue 5 Pt 1 Pg. 705-11 (May 1998) ISSN: 0190-9622 [Print] United States
PMID9591815 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Dermatologic Agents
  • Gels
  • Glucocorticoids
  • Nicotinic Acids
  • Prodrugs
  • Fluocinonide
  • tazarotene
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Child
  • Dermatologic Agents (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
  • Erythema (drug therapy, pathology)
  • Female
  • Fluocinonide (administration & dosage, therapeutic use)
  • Follow-Up Studies
  • Gels
  • Glucocorticoids
  • Humans
  • Life Tables
  • Male
  • Middle Aged
  • Nicotinic Acids (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
  • Prodrugs (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
  • Psoriasis (drug therapy, pathology)
  • Safety
  • Single-Blind Method
  • Skin (pathology)
  • Treatment Outcome

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