Abstract | OBJECTIVE: METHODS: Ten patients were identified using a computerized data base available at this institution. The clinical and pathological materials, when available, were reviewed, and each tumor reviewed was assigned a Hyams' grade. RESULTS: There were six men and four women, ranging in age from 22 to 74 years, all of whom had assessable Kadish Stage C disease at the time of chemotherapy treatment. The chemotherapy regimens and clinical follow-up varied during this 25-year time span. The only tumor regression resultant from chemotherapy was observed in patients with high-grade tumors. Two of four patients with high-grade tumors obtained regression from first-line, platinum-based chemotherapy, with a mean duration of regression of 9.3 months (range, 2-13 mo). Survival time from initial diagnosis was 139.5 months (range, 83-168 mo) in patients with low-grade tumors and 32.2 months (range, 5-84 mo) in patients with high-grade tumors. Survival from initial chemotherapy treatment was 44.5 months (range, 3-130 mo) in patients with low-grade tumors and 26.5 months (range, 2-67 mo) in patients with high-grade tumors. CONCLUSION:
|
Authors | E A McElroy Jr, J C Buckner, J E Lewis |
Journal | Neurosurgery
(Neurosurgery)
Vol. 42
Issue 5
Pg. 1023-7; discussion 1027-8
(May 1998)
ISSN: 0148-396X [Print] United States |
PMID | 9588546
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Cytarabine
- Mitomycin
- Vincristine
- Etoposide
- Doxorubicin
- Cyclophosphamide
- Mesna
- Cisplatin
- Carmustine
- Ifosfamide
- Methotrexate
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brain Neoplasms
(drug therapy, secondary, therapy)
- Carmustine
(administration & dosage)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Cytarabine
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Esthesioneuroblastoma, Olfactory
(drug therapy, mortality, pathology, secondary, therapy)
- Etoposide
(administration & dosage)
- Fatal Outcome
- Female
- Humans
- Ifosfamide
(administration & dosage)
- Lymphatic Metastasis
- Male
- Mesna
(administration & dosage)
- Methotrexate
(administration & dosage)
- Middle Aged
- Mitomycin
(administration & dosage)
- Nasal Cavity
- Nose Neoplasms
(drug therapy, mortality, pathology, therapy)
- Paranasal Sinus Neoplasms
(drug therapy, mortality, pathology, therapy)
- Remission Induction
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
- Vincristine
(administration & dosage)
|