Abstract | SETTING: A residential program in Barcelona for drug addicts (therapeutic community) admitted between November 1988 and March 1992, and followed until September 1994. OBJECTIVE: DESIGN: Prospective cohort study. Incidence rates were compared using the Chi-square test for cohort studies. The effectiveness of chemoprophylaxis was evaluated by the Kaplan-Meier method at the univariate level, and by logistic regression models and proportional risks analysis at the multivariate level. RESULTS: During the study of 361 individuals without previous known tuberculosis or history of anti- tuberculosis chemoprophylaxis, 25 developed tuberculosis, an overall incidence rate of 1.79/100 person-years. For HIV-positive persons, the incidence rate was 3.25/100 person-years, compared with 0.30/100 in those who were HIV-negative (P < 0.05). The highest incidence rates occurred among HIV-positive persons who did not receive chemoprophylaxis and who were either anergic (HIV-positive, purified protein derivative [ PPD]-negative, Multitest-negative) or who were infected with Mycobacterium tuberculosis ( PPD+), 10.0/100 person-years and 4.64/100 person-years, respectively. Of the 53 persons who received chemoprophylaxis, three developed tuberculosis, an incidence rate of 1.4/100 person-years. In comparison, in the group of 51 patients who were designated to receive chemoprophylaxis but where none was actually taken, 17 developed tuberculosis, an incidence rate of 5.7/100 person-years (P = 0.03). CONCLUSION: HIV-infected intravenous drug users, particularly those who are anergic or who are PPD positive, are at increased risk of developing tuberculosis. Anti- tuberculosis chemoprophylaxis proved effective in this population.
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Authors | J M Jansà, J Serrano, J A Caylà, R Vidal, I Ocaña, T Español |
Journal | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
(Int J Tuberc Lung Dis)
Vol. 2
Issue 2
Pg. 140-6
(Feb 1998)
ISSN: 1027-3719 [Print] France |
PMID | 9580481
(Publication Type: Journal Article)
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Chemical References |
- Antitubercular Agents
- Isoniazid
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Topics |
- AIDS-Related Opportunistic Infections
(epidemiology, prevention & control)
- Adult
- Antitubercular Agents
(therapeutic use)
- Cohort Studies
- Female
- HIV Infections
(epidemiology)
- Humans
- Incidence
- Isoniazid
(therapeutic use)
- Male
- Multivariate Analysis
- Prospective Studies
- Risk Factors
- Spain
(epidemiology)
- Substance Abuse, Intravenous
(epidemiology)
- Therapeutic Community
- Tuberculin Test
- Tuberculosis, Pulmonary
(epidemiology, prevention & control)
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