Abstract |
In an open, randomized study of 60 patients with acute or recurrent sinusitis, the bacteriological and clinical efficacy of roxithromycin 150 mg bd were compared with those of po co-amoxiclav (625 mg) tds. Of 52 patients who underwent sinus puncture for isolation of causative organisms, 48 had pathogens sensitive to both antibiotics. Satisfactory clinical response was obtained in 93.1% (27/29) evaluable patients receiving roxithromycin and 88.8% (24/27) receiving co-amoxiclav. Tolerability was significantly better in the roxithromycin group, with 1/29 (3.4%) patients in this group experiencing gastrointestinal side-effects, compared with 7/27 (25.9%) patients in the co-amoxiclav group (P < 0.05). Although the study had limited power to detect differences, roxithromycin demonstrated clinical, bacteriological and overall efficacy similar to that of co-amoxiclav, but with better tolerability. Roxithromycin thus appears to be an effective and well-tolerated drug for the treatment of acute and recurrent sinusitis.
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Authors | E Chatzimanolis, N Marsan, D Lefatzis, A Pavlopoulos |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 41 Suppl B
Pg. 81-4
(Mar 1998)
ISSN: 0305-7453 [Print] England |
PMID | 9579718
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Roxithromycin
- Amoxicillin-Potassium Clavulanate Combination
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Topics |
- Adolescent
- Adult
- Aged
- Amoxicillin-Potassium Clavulanate Combination
(adverse effects, therapeutic use)
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Bacteroides Infections
(drug therapy)
- Bacteroides fragilis
- Drug Therapy, Combination
(adverse effects, therapeutic use)
- Female
- Haemophilus Infections
(drug therapy)
- Haemophilus influenzae
- Humans
- Male
- Middle Aged
- Moraxella catarrhalis
- Neisseriaceae Infections
(drug therapy)
- Pneumococcal Infections
(drug therapy)
- Roxithromycin
(adverse effects, therapeutic use)
- Sinusitis
(drug therapy)
- Staphylococcal Infections
(drug therapy)
- Streptococcus pneumoniae
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