Abstract | BACKGROUND: AIMS: METHODS: Glasgow score, Apache II, computed tomography (CT) scan score, C reactive protein (CRP), serum IgM antiendotoxin antibodies (EndoCAb), and total antioxidant capacity (TAC) were determined on admission in 34 patients with acute pancreatitis. Patients were stratified according to disease severity and randomised to receive either TPN or TEN for seven days and then re-evaluated. RESULTS: SIRS, sepsis, organ failure, and ITU stay, were globally improved in the enterally fed patients. The acute phase response and disease severity scores were significantly improved following enteral nutrition (CRP: 156 (117-222) to 84 (50-141), p < 0.005; APACHE II scores 8 (6-10) to 6 (4-8), p < 0.0001) without change in the CT scan scores. In parenterally fed patients these parameters did not change but there was an increase in EndoCAb antibody levels and a fall in TAC. Enterally fed patients showed no change in the level of EndoCAb antibodies and an increase in TAC. CONCLUSION:
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Authors | A C Windsor, S Kanwar, A G Li, E Barnes, J A Guthrie, J I Spark, F Welsh, P J Guillou, J V Reynolds |
Journal | Gut
(Gut)
Vol. 42
Issue 3
Pg. 431-5
(Mar 1998)
ISSN: 0017-5749 [Print] England |
PMID | 9577354
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antibodies
- Endotoxins
- Immunoglobulin M
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Topics |
- APACHE
- Acute Disease
- Acute-Phase Reaction
(therapy)
- Aged
- Antibodies
(blood)
- Endotoxins
(immunology)
- Enteral Nutrition
- Female
- Humans
- Immunoglobulin M
(blood)
- Male
- Middle Aged
- Oxidative Stress
- Pancreatitis
(immunology, therapy)
- Parenteral Nutrition, Total
- Systemic Inflammatory Response Syndrome
(prevention & control)
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