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Increase in monoamine levels caused by emotional stress in mice brain regions is attenuated by Saiko-ka-ryukotsu-borei-to.

Abstract
The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced increase of monoamines in brain regions was investigated in three mouse emotional stress models. Dopamine (DA) and 3,4-dihydroxy-phenyl acetic acid (DOPAC) contents were elevated significantly by electric shock stress, psychological stress and conditioned fear stress in thalamus, hypothalamus and amygdala. The DA and DOPAC levels were decreased by preadministration of SRBT (600 mg/kg, p.o.) in the last two models, but were not altered in electric shock stress. Therefore, this compound seems to be effective in stress involving emotional factors. These results indicate that SRBT affects the brain monoamine neurons leading to psychological change in mice.
AuthorsK Sasaki, K Suzuki, M Ueno, K Takako, F Yoshizaki
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) 1998 Jan-Feb Vol. 20 Issue 1 Pg. 27-30 ISSN: 0379-0355 [Print] Spain
PMID9575479 (Publication Type: Journal Article)
Chemical References
  • Drugs, Chinese Herbal
  • saiko-ka-ryukotsu-borei-to
  • 3,4-Dihydroxyphenylacetic Acid
  • Dopamine
Topics
  • 3,4-Dihydroxyphenylacetic Acid (analysis)
  • Animals
  • Brain Chemistry (drug effects)
  • Dopamine (analysis)
  • Drugs, Chinese Herbal (pharmacology)
  • Male
  • Mice
  • Stress, Psychological (metabolism)

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