Abstract | BACKGROUND: METHODS AND RESULTS: We studied endothelial vasomotor function in 100 healthy postmenopausal women aged 53.3+/-2.9 years randomized to either combined hormone replacement therapy (n=46) or no substitution (n=54) 2.9+/-0.5 years earlier. In addition, 30 healthy premenopausal women aged 30.3+/-4.2 years were studied. With external ultrasound, brachial artery diameter was measured at rest, during reactive hyperemia (with increased flow causing endothelium-dependent dilation), and after sublingual nitroglycerin (causing endothelium-independent dilation). Compared with premenopausal women, flow-mediated dilation was significantly reduced in both postmenopausal groups. In the postmenopausal women, total cholesterol was lower in the treated women (5.66+/-0.83 versus 6.13+/-0.92 mmol/L; P=.025), whereas HDL cholesterol was similar (1.91+/-0.53 versus 1.85+/-0.46 mmol/L; P=NS). Dilation to flow and to nitroglycerin was similar in the two postmenopausal groups (flow: 2.5+/-2.9% versus 2.2+/-2.2%, P=NS; nitrate: 18.7+/-5.9% versus 17.2+/-6.2%, P=NS). CONCLUSIONS:
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Authors | K E Sorensen, I Dorup, A P Hermann, L Mosekilde |
Journal | Circulation
(Circulation)
Vol. 97
Issue 13
Pg. 1234-8
(Apr 07 1998)
ISSN: 0009-7322 [Print] United States |
PMID | 9570192
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aging
(drug effects)
- Coronary Disease
(prevention & control)
- Denmark
- Drug Therapy, Combination
- Endothelium, Vascular
(drug effects)
- Estrogen Replacement Therapy
- Female
- Humans
- Middle Aged
- Postmenopause
(drug effects)
- Premenopause
- Progesterone
(therapeutic use)
- Prospective Studies
- Vasomotor System
(drug effects)
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