Abstract |
It has been shown recently that activation of forebrain serotonin1A (5-HT1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT1A receptor agonist R(+)-8-hydroxy-2-(di-n-propylamino) tetralin [R(+)8- OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT2 and 5-HT3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8- OH-DPAT. The data suggest that activation of 5-HT1A receptors, but not 5-HT2 or 5-HT3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area.
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Authors | A Szabó, B L Butz, R H Alper |
Journal | Brain research bulletin
(Brain Res Bull)
Vol. 45
Issue 6
Pg. 583-8
(Apr 1998)
ISSN: 0361-9230 [Print] United States |
PMID | 9566502
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptor, Serotonin, 5-HT2A
- Receptors, Serotonin
- Receptors, Serotonin, 5-HT1
- Receptors, Serotonin, 5-HT3
- 5,7-Dihydroxytryptamine
- Serotonin
- 8-Hydroxy-2-(di-n-propylamino)tetralin
- Buspirone
- Dopamine
- Norepinephrine
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Topics |
- 5,7-Dihydroxytryptamine
(pharmacology)
- 8-Hydroxy-2-(di-n-propylamino)tetralin
(pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Buspirone
(pharmacology)
- Dopamine
(metabolism)
- Heart Rate
(drug effects)
- Male
- Norepinephrine
(pharmacology)
- Preoptic Area
(drug effects, physiology, physiopathology)
- Prosencephalon
(drug effects, physiology, physiopathology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT2A
- Receptors, Serotonin
(drug effects, physiology)
- Receptors, Serotonin, 5-HT1
- Receptors, Serotonin, 5-HT3
- Serotonin
(metabolism, pharmacology)
- Synapses
(physiology)
- Tachycardia
(physiopathology)
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