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Cerebral vasculitis during FK 506 treatment in a liver transplant patient.

Abstract
The immunosuppressive agent FK 506 is widely used in liver transplant patients. Neurotoxicity is a major complication of its use. We report progressive and irreversible neurologic complications occurring in a 39-year-old woman who underwent liver transplantation and was treated with FK 506. Neuropathologic examination revealed multiple vasculitic lesions. The possibility of an FK 506-mediated toxic effect on the cerebral vessels is suggested.
AuthorsG P Pizzolato, R Sztajzel, K Burkhardt, M Megret, B Borisch
JournalNeurology (Neurology) Vol. 50 Issue 4 Pg. 1154-7 (Apr 1998) ISSN: 0028-3878 [Print] United States
PMID9566415 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Neurotoxins
  • Tacrolimus
Topics
  • Adult
  • Cerebral Arteries (pathology)
  • Cerebrovascular Circulation
  • Fatal Outcome
  • Female
  • Humans
  • Immunosuppressive Agents (toxicity)
  • Liver Transplantation
  • Magnetic Resonance Imaging
  • Neurotoxins (adverse effects)
  • Tacrolimus (toxicity)
  • Vasculitis (chemically induced, diagnosis)

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