Abstract |
The immunosuppressive agent FK 506 is widely used in liver transplant patients. Neurotoxicity is a major complication of its use. We report progressive and irreversible neurologic complications occurring in a 39-year-old woman who underwent liver transplantation and was treated with FK 506. Neuropathologic examination revealed multiple vasculitic lesions. The possibility of an FK 506-mediated toxic effect on the cerebral vessels is suggested.
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Authors | G P Pizzolato, R Sztajzel, K Burkhardt, M Megret, B Borisch |
Journal | Neurology
(Neurology)
Vol. 50
Issue 4
Pg. 1154-7
(Apr 1998)
ISSN: 0028-3878 [Print] United States |
PMID | 9566415
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Neurotoxins
- Tacrolimus
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Topics |
- Adult
- Cerebral Arteries
(pathology)
- Cerebrovascular Circulation
- Fatal Outcome
- Female
- Humans
- Immunosuppressive Agents
(toxicity)
- Liver Transplantation
- Magnetic Resonance Imaging
- Neurotoxins
(adverse effects)
- Tacrolimus
(toxicity)
- Vasculitis
(chemically induced, diagnosis)
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