Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia.

Abstract	Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
Authors	M S Bartlett, M M Shaw, J W Smith, S R Meshnick
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 42 Issue 4 Pg. 934-5 (Apr 1998) ISSN: 0066-4804 [Print] United States
PMID	9559812 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Infective Agents Trimethoprim, Sulfamethoxazole Drug Combination Sulfamethoxypyridazine
Topics	Animals Anti-Infective Agents (therapeutic use) Mice Mice, Inbred BALB C Pneumonia, Pneumocystis (drug therapy) Rats Sulfamethoxypyridazine (therapeutic use) Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)

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