Abstract | OBJECTIVE: DESIGN: SETTING: Basic science research laboratory in an academic institution. PARTICIPANTS: Sprague-Dawley male rats weighing 300g. INTERVENTION: Three episodes of induced AD hypertension with bowel distension for 1 minute. RESULTS: Results showed a significant difference between groups 1 and 2, 2 and 3, and 1 and 3 (p=.0002, ANOVA, Y1/2, post hoc Tukey). The mean NE levels in groups 1, 2, and 3 were 465+/-400 ng/mL, 1,328+/-1,116 ng/mL, and 31+/-61 ng/mL, respectively. CONCLUSION: NE increased during AD in the spinal cord injured rat. NE levels were effectively blocked by 6-OH DA when AD was induced. Knowledge of catecholamine levels in this process may assist in determining both pathophysiology and potential pharmacologic treatment options in future human studies.
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Authors | F Y Chiou-Tan, C S Robertson, G C Chiou |
Journal | Archives of physical medicine and rehabilitation
(Arch Phys Med Rehabil)
Vol. 79
Issue 4
Pg. 402-4
(Apr 1998)
ISSN: 0003-9993 [Print] United States |
PMID | 9552105
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Evaluation Studies as Topic
- Male
- Norepinephrine
(blood)
- Prospective Studies
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reflex, Abnormal
- Spinal Cord Injuries
(blood, complications)
- Sympathectomy, Chemical
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