Abstract | BACKGROUND: METHODS: Four i.v. infusions of propacetamol 2 g or placebo were administered, in a double-blind fashion, after orthopedic surgery (n = 97). Morphine was administered by a patient-controlled analgesia (PCA) device. The total dose of morphine, pain intensity and global efficacy of treatment were evaluated. Tolerability was assessed by monitoring blood pressure, heart and respiratory rate, sedation scores, adverse events, and renal and hepatic parameters. RESULTS: The total dose of morphine was significantly decreased in the propacetamol group compared to placebo (9.4 +/- 8.5 mg vs 17.6 +/- 12 mg; P < 0.001), arriving at a sparing effect of 46%. The evolution of pain intensity showed a similar pattern in the two groups. Global efficacy of treatment was rated significantly better by patients receiving the combination propacetamol + PCA morphine (87% of "good"/"excellent" ratings vs 65%; P = 0.01). Tolerability was comparable in the two groups. Eight patients in the propacetamol and 4 patients in the placebo group reported adverse events, of mild/moderate intensity, most commonly nausea/ vomiting. Renal and hepatic parameters were also seen to be comparable. CONCLUSION:
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Authors | V A Peduto, M Ballabio, S Stefanini |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 42
Issue 3
Pg. 293-8
(Mar 1998)
ISSN: 0001-5172 [Print] England |
PMID | 9542555
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Acetaminophen
- propacetamol
- Morphine
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Topics |
- Acetaminophen
(analogs & derivatives, therapeutic use)
- Adolescent
- Adult
- Aged
- Analgesia, Patient-Controlled
- Analgesics
(therapeutic use)
- Analgesics, Opioid
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Morphine
(administration & dosage)
- Orthopedics
- Pain Measurement
- Pain, Postoperative
(drug therapy)
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