[The value of cardiac troponin I as diagnostic test in the study of chest pain].

Abstract

BACKGROUND AND OBJECTIVES:

Cardiac troponin I is a highly sensitive and specific myocardial injury marker. We have analyzed the use of cardiac troponin I values in the diagnosis of coronary artery disease, in previously healthy patients who developed chest pain with inconclusive analytical and ECG diagnostic findings.

PATIENTS, MATERIAL AND METHODS:

A one year cross-sectional consecutive study was conducted, in a total of 37 patients with no previously known heart disease who were admitted to the coronary unit for suspected anginal chest pain with normal cardiac enzymes and ECG. Abnormal cardiac troponin I levels at admission were defined as > or = 0.4 ng/ml, and were compared with coronary angiography or exercise test results and related to the duration of pain and the time from the appearance of symptoms to blood extraction.

RESULTS:

Thirty-three of the 37 initially included patients were studied. Coronary artery disease was diagnosed in 22, 15 of whom had increased troponin I values, yielding a sensitivity of 68% (48%-84%) and a specificity of 82% (53%-97%). In the subgroup of patients with pain lasting > 30 min, sensitivity reached 85% (59%-97%) and specificity 83% (42%-99%). There were no significant differences between subgroups with different time delays from appearance of symptoms to blood extraction.

CONCLUSIONS:

Cardiac troponin I is very useful for the studying ischemic chest pain without a definitive diagnostic ECG nor biochemical data, resulting in a high sensitivity and specificity for myocardial ischemic injury detection. Its diagnostic value increases in cases of prolonged pain episodes.

• Authors: B García de la Villa, I Díaz-Buschmann, J Alfonso Jurado, R García, F Javier Parra, J Medina, M A San Martín, M de los Reyes, A Hernández-Madrid, J Manuel del Rey, J Manuel Escribano
• Journal: Revista espanola de cardiologia (Rev Esp Cardiol) Vol. 51 Issue 2 Pg. 122-8 (Feb 1998) ISSN: 0300-8932 [Print] Spain
• Vernacular Title: Valor de la troponina I cardíaca como prueba diagnóstica en el estudio del dolor torácico.
• PMID: 9542435 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Isoenzymes
• Troponin I
• Creatine Kinase

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Chest Pain (blood)
• Creatine Kinase (blood)
• Cross-Sectional Studies
• Female
• Humans
• Isoenzymes
• Male
• Middle Aged
• Myocardial Ischemia (blood, diagnosis)
• Sensitivity and Specificity
• Troponin I (blood)