Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions.

Abstract

The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1 to S state.

• Authors: T Sato, M Hashizume, Y Hotta, Y Okahata
• Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (Biometals) Vol. 11 Issue 2 Pg. 107-12 (Apr 1998) ISSN: 0966-0844 [Print] Netherlands
• PMID: 9542064 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Metals, Rare Earth
• Aluminum

Topics

• Aluminum (pharmacology)
• Animals
• Cell Cycle (drug effects)
• Cell Division (drug effects)
• Cell Size (drug effects)
• Cytoskeleton (drug effects)
• HeLa Cells
• Humans
• Kinetics
• Melanoma, Experimental (drug therapy, pathology)
• Metals, Rare Earth (pharmacology)
• Mice
• Tumor Cells, Cultured