Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome.

Abstract

A detailed history of a boy with Landau-Kleffner syndrome is presented, demonstrating a close relationship between language functioning and paroxysmal electroencephalogram activity. During a 3-year 6-month follow-up period, three abrupt deteriorations of all language functions occurred: the child became totally noninteractive with his environment within 1 week's time. Two of these deteriorations were reversed with steroid treatment, with an identical recovery phase. Intravenous immunoglobulins had a very dramatic and comparable effect in the third relapse; both language functions and electroencephalogram abnormalities were influenced significantly by the intravenous immunoglobulin treatment.

• Authors: L G Lagae, J Silberstein, P L Gillis, P J Casaer
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 18 Issue 2 Pg. 165-8 (Feb 1998) ISSN: 0887-8994 [Print] United States
• PMID: 9535304 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Child
• Electroencephalography
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Landau-Kleffner Syndrome (complications, therapy)
• Language Disorders (etiology, therapy)
• Male
• Neuropsychological Tests