Abstract | BACKGROUND: METHODS: Pneumococcal conjugate vaccine, containing capsular polysaccharides from serotypes 6B, 14, 19F and 23F conjugated to diphtheria toxoid (PncD), was given to 75 infants at 2, 4 and 6 months of age. Three dosages (1, 3 or 10 microg of each) were used. A placebo group of 49 infants received physiologic saline. Children were given a booster dose of either polysaccharide or conjugate vaccine at 14 months of age; the placebo group received conjugate vaccine. Antibody concentrations were determined with an enzyme immunoassay. RESULTS: The highest dose induced the strongest response after primary immunization, but booster response was greatest in the group primed with the lowest dose. Polysaccharide and conjugate vaccines induced booster responses of the same magnitude. At 24 and 36 months of age the antibody concentrations were similar in children who had received the PncD in infancy and in children immunized at 14 months of age only. CONCLUSIONS:
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Authors | H Ahman, H Käyhty, H Lehtonen, O Leroy, J Froeschle, J Eskola |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 17
Issue 3
Pg. 211-6
(Mar 1998)
ISSN: 0891-3668 [Print] United States |
PMID | 9535248
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Bacterial Vaccines
- Diphtheria Toxoid
- Pneumococcal Vaccines
- Polysaccharides, Bacterial
- Vaccines, Conjugate
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Topics |
- Antibodies, Bacterial
(biosynthesis)
- Bacterial Vaccines
(administration & dosage, immunology)
- Diphtheria Toxoid
(administration & dosage, immunology)
- Humans
- Immunization Schedule
- Immunologic Memory
- Infant
- Pneumococcal Vaccines
- Polysaccharides, Bacterial
(immunology)
- Streptococcus pneumoniae
(immunology)
- Vaccines, Conjugate
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