Abstract | OBJECTIVE: METHODS: RESULTS: Four hundred patients (23%) had a history of arterial hypertension. A total of 173 (43%) patients with a history of hypertension died during follow up versus 500 (37%) patients in the normotensive group. Treatment with trandolapril in the hypertensive individuals was associated with a reduction in the relative risk of death to 0.59 (95% confidence interval 0.44-0.80), versus 0.85 (0.72-1.02) in the normotensive individuals. The significant reduction in mortality in hypertensive individuals persisted after multivariate analysis controlling for a broad spectrum of potential confounders. Also, benefit from ACE inhibition increased with increasing blood pressure at the time of randomization. Significant interactions between benefit from ACE inhibition and hypertension history, and systolic and diastolic blood pressure were found. CONCLUSION: ACE inhibition after AMI complicated by left ventricular dysfunction may be of particular importance in patients with a history of arterial hypertension or a relatively high pretreatment blood pressure. However, further investigations are necessary to establish the clinical impact of these results.
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Authors | F Gustafsson, L Køber, C Torp-Pedersen, Per Hildebrandt |
Journal | Journal of hypertension. Supplement : official journal of the International Society of Hypertension
(J Hypertens Suppl)
Vol. 16
Issue 1
Pg. S65-70
(Jan 1998)
ISSN: 0952-1178 [Print] England |
PMID | 9534100
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Indoles
- trandolapril
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Topics |
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Blood Pressure
(drug effects, physiology)
- Double-Blind Method
- Female
- Humans
- Hypertension
(complications, drug therapy, physiopathology)
- Indoles
(therapeutic use)
- Male
- Medical Records
- Myocardial Infarction
(complications)
- Ventricular Dysfunction, Left
(complications)
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