Syndromes of thyrotoxicosis with low radioactive iodine uptake.

Abstract

It is very important to diagnose correctly the etiology of thyrotoxicosis, because the course and treatment of thyrotoxicosis with low radioactive iodine uptake differ significantly from that of hyperthyroidism due to Graves' disease or toxic nodular goiter. Many causes of subacute thyroiditis have been identified producing a characteristic course of transient hyperthyroidism, followed by hypothyroidism, and usually recovery. Ectopic hyperthyroidism includes factitious thyroid hormone ingestion, struma ovarii, and, rarely, large deposits of functioning thyroid cancer metastases. Iodine-induced hyperthyroidism may be associated with low radioiodine uptakes. Amiodarone-associated hyperthyroidism may be the result of subacute thyroiditis or iodine-induced hyperthyroidism; assessment and treatment can be quite challenging.

• Authors: D S Ross
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 27 Issue 1 Pg. 169-85 (Mar 1998) ISSN: 0889-8529 [Print] United States
• PMID: 9534035 (Publication Type: Journal Article, Review)

Chemical References

• Iodine Radioisotopes
• Iodine

Topics

• Humans
• Hyperthyroidism (chemically induced)
• Iodine (adverse effects)
• Iodine Radioisotopes (metabolism)
• Syndrome
• Thyroiditis, Subacute (classification, diagnosis, etiology, therapy)
• Thyrotoxicosis (classification, metabolism)