HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Local treatment of purulent chronic otitis media with ciprofloxacin].

Abstract
We evaluated the efficacy of ciprofloxacin eardrops compared to tobramycin and to a placebo in the treatment of chronic suppurative otitis media. 60 ears were randomly assigned to treatment for 3 weeks with ciprofloxacin, tobramycin or placebo eardrops. The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. The clinical responses were 78.9% and 72.2%, respectively, in the ciprofloxacin and tobramycin groups, while it was only 41.2% in the placebo group. Treatment with ciprofloxacin eardrops seemed to be at least as efficient as treatment with tobramycin. Considering the lack of ototoxicity of ciprofloxacin, this treatment may be best for chronic otitis media.
AuthorsL Podoshin, A Brodzki, M Fradis, J Ben-David, J Larboni, I Srugo
JournalHarefuah (Harefuah) Vol. 134 Issue 1 Pg. 32-6, 78 (Jan 01 1998) ISSN: 0017-7768 [Print] Israel
PMID9517277 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Pharmaceutical Solutions
  • Ciprofloxacin
  • Tobramycin
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Anti-Infective Agents (administration & dosage, therapeutic use)
  • Chronic Disease
  • Ciprofloxacin (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Otitis Media, Suppurative (drug therapy, microbiology)
  • Pharmaceutical Solutions
  • Pseudomonas Infections (drug therapy)
  • Tobramycin (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: