[Salsolinol, 3-O-methyl-dopa and homovanillic acid in the cerebrospinal fluid of Parkinson patients].

Abstract

Salsolinol is one of the dopamine-derived tetrahydroisoquinolines, supposed to be a potent dopaminergic neurotoxin, similar to MPTP. Its systemic administration induced parkinsonism in monkeys. The aim of the study was to compare the concentration of salsolinol and the metabolite of L-dopa, 3-O-MD, and the metabolite of dopamine, HVA, in the cerebrospinal fluid of patients with different degrees of parkinsonism, treated or nontreated with l-dopa. Lumbar CSF was obtained from 26 patients with Parkinson's disease (15 early and 11 advanced parkinsonism) and from six healthy controls. The presence of salsolinol, HVA and 3-O-MD was assayed with a sensitive HPLC method employing C18 (Hypersil BDS) column. The analysis of the results demonstrated that the concentration of salsolinol was related to the degree of parkinsonism but not affected by l-dopa treatment. In contrast, HVA and 3-O-MD were significantly elevated in patients receiving l-dopa but did not correlate with the severity of parkinsonism. The results suggest that salsolinol in the cerebrospinal fluid does not originate from exogenous l-dopa and its elevation in cerebrospinal fluid may be an indicator of the advancement of parkinsonism.

• Authors: A Krygowska-Wajs, A Szczudlik, L Antkiewicz-Michaluk, I Romańska, J Vetulani
• Journal: Neurologia i neurochirurgia polska (Neurol Neurochir Pol) 1997 Sep-Oct Vol. 31 Issue 5 Pg. 875-85 ISSN: 0028-3843 [Print] Poland
• Vernacular Title: Salsolinol oraz 3-0-metyldopa i kwas homowanilinowy w płynie mózgowo-rdzeniowym u osób z choroba parkinsona.
• PMID: 9513952 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiparkinson Agents
• Isoquinolines
• Tyrosine
• Levodopa
• salsolinol
• 3-methoxytyrosine
• Homovanillic Acid

Topics

• Aged
• Aged, 80 and over
• Antiparkinson Agents (therapeutic use)
• Chromatography, High Pressure Liquid (methods)
• Female
• Homovanillic Acid (cerebrospinal fluid, therapeutic use)
• Humans
• Isoquinolines (cerebrospinal fluid)
• Levodopa (therapeutic use)
• Male
• Middle Aged
• Parkinson Disease (cerebrospinal fluid, drug therapy)
• Severity of Illness Index
• Tyrosine (analogs & derivatives, cerebrospinal fluid)