Abstract |
Quinupristin/dalfopristin is a new water-soluble streptogramin antimicrobial agent comprising quinupristin and dalfopristin in a ratio of 30:70. The in-vitro spectrum of activity includes most multi-resistant Gram-positive aerobes, important Gram-negative aerobes, Gram-positive anaerobes and intracellular bacteria that are causal agents of respiratory, blood and cutaneous infections. Of particular note, quinupristin/dalfopristin is active against multidrug-resistant isolates of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium, and against penicillin-resistant and/or erythromycin-resistant Streptococcus pneumoniae. The combination is also active against staphylococci showing both constitutive and inducible erythromycin resistance. Bactericidal activity and a prolonged post- antibiotic effect have also been noted for quinupristin/dalfopristin against Gram-positive cocci. Gram-negative bacteria susceptible to quinupristin/dalfopristin include Moraxella catarrhalis, Legionella spp. and Mycoplasma spp. Overall, the spectrum of antibacterial activity indicates a potential role for this combination in the treatment of difficult-to-treat Gram-positive infections, including those caused by multidrug-resistant organisms. Since this activity extends to Gram-negative respiratory bacteria, quinupristin/dalfopristin may also find a role in the treatment of atypical, as well as typical, pneumonia.
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Authors | D H Bouanchaud |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 39 Suppl A
Pg. 15-21
(May 1997)
ISSN: 0305-7453 [Print] England |
PMID | 9511057
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Virginiamycin
- quinupristin-dalfopristin
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Topics |
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Drug Resistance, Microbial
- Enterococcus
(drug effects)
- Gram-Negative Bacteria
(drug effects)
- Gram-Positive Bacteria
(drug effects)
- Humans
- Microbial Sensitivity Tests
- Penicillin Resistance
- Pneumonia
(drug therapy)
- Staphylococcus
(drug effects)
- Streptococcus
(drug effects)
- Virginiamycin
(pharmacology, therapeutic use)
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