Abstract | OBJECTIVE: To determine whether intra-umbilical vein injection with saline solution, with or without oxytocin, reduces the need for manual removal of placenta compared with expectant management. DESIGN: Multicenter, randomised controlled trial. SETTING: Eleven hospitals in four cities of Argentina: Buenos Aires, Corrientes, Rosario, and Salta. PARTICIPANTS: Two hundred and ninety-one women showing no evidence of placental separation thirty minutes after vaginal delivery. INTERVENTIONS: Three different management strategies: 1. intra-umbilical vein injection of saline solution plus oxytocin; 2. intra-umbilical vein injection of saline solution alone; and 3. expectant management. MAIN OUTCOME MEASURES: RESULTS: Rates of subsequent manual removal were similar: intra-umbilical vein injection of saline solution plus oxytocin (58%; RR 0.92; 95% CI 0.73-1.15), or saline alone (63%; RR 1.00; 95% CI 0.80-1.24), compared with expectant management (63%). There were also no detectable effects of the active managements on any of the secondary measures of outcome. CONCLUSIONS: Based on evidence available from randomised controlled trials, including this trial, it is unlikely that intra-umbilical injection with or without oxytocin, is clinically useful. We recommend that this intervention should not be used in third stage management of labour.
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Authors | G Carroli, J M Belizan, A Grant, L Gonzalez, L Campodonico, E Bergel |
Journal | British journal of obstetrics and gynaecology
(Br J Obstet Gynaecol)
Vol. 105
Issue 2
Pg. 179-85
(Feb 1998)
ISSN: 0306-5456 [Print] England |
PMID | 9501783
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Female
- Follow-Up Studies
- Humans
- Injections, Intravenous
- Oxytocin
(administration & dosage)
- Placenta, Retained
(prevention & control)
- Pregnancy
- Sodium Chloride
(administration & dosage)
- Treatment Outcome
- Umbilical Veins
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