Abstract | BACKGROUND: METHODS: RESULTS:
Homocysteine concentrations were higher in recipients than controls (19.1+/-13.0 vs. 11.0+/-3.0 micromol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.6 micromol/L) was seen in 68% of recipients (P<0.01). Folate and vitamin B6 concentrations were lower (5.9+/-4.2 vs. 7.9+/-4.2 pmol/L and 40+/-25 vs. 84+/-77 nmol/L, respectively; P<0.01 for both). Folate and vitamin B6 deficiencies were seen in 10.8% and 17.91% of recipients, respectively (P<0.01). Hyperhomocysteinemia was more frequent in patients with vascular complications after transplantation than in those without (79.2% vs. 63.8%, P<0.05). CONCLUSIONS: Elevated plasma homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients. A high homocysteine concentration was more common in patients with vascular complications. Prospective studies are now required to evaluate the role of these abnormalities as risk factors for the atherothrombotic complications of transplantation.
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Authors | A Gupta, A Moustapha, D W Jacobsen, M Goormastic, E M Tuzcu, R Hobbs, J Young, K James, P McCarthy, F van Lente, R Green, K Robinson |
Journal | Transplantation
(Transplantation)
Vol. 65
Issue 4
Pg. 544-50
(Feb 27 1998)
ISSN: 0041-1337 [Print] United States |
PMID | 9500631
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Homocysteine
- Folic Acid
- Pyridoxine
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Topics |
- Arteriosclerosis
(epidemiology, mortality)
- Biomarkers
(blood)
- Coronary Thrombosis
(epidemiology, mortality)
- Female
- Folic Acid
(blood)
- Folic Acid Deficiency
(complications, epidemiology)
- Follow-Up Studies
- Heart Transplantation
(mortality, physiology)
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Morbidity
- Postoperative Complications
(blood, epidemiology)
- Pyridoxine
(blood)
- Retrospective Studies
- Risk Factors
- Time Factors
- Vitamin B 6 Deficiency
(complications, epidemiology)
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