Abnormally soluble collagen produced in fibroblasts cultures.

Abstract

Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. The excessive solubility of collagen is corrected by the addition to the culture medium of a synthetic flavonoid, (+)- catechin.

• Authors: G Francis, P V Donnelly, N Di Ferrante
• Journal: Experientia (Experientia) Vol. 32 Issue 6 Pg. 691-3 (Jun 15 1976) ISSN: 0014-4754 [Print] Switzerland
• PMID: 950007 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzopyrans
• Collagen
• Hydroxyproline

Topics

• Benzopyrans (pharmacology)
• Cells, Cultured
• Collagen (metabolism)
• Cutis Laxa (metabolism)
• Ehlers-Danlos Syndrome (metabolism)
• Fibroblasts (metabolism)
• Humans
• Hydroxyproline (metabolism)
• Marfan Syndrome (metabolism)
• Skin