Abstract | BACKGROUND & AIMS: METHODS: RESULTS: After photodynamic therapy, bilirubin serum levels declined from 318 +/- 72 to 103 +/- 35 micromol/L (P = 0.0039) with no significant increase during the two monthly follow-ups. Quality of life indices improved dramatically and remained stable (e.g., Karnofsky index from 32.2% +/- 8.13% to 68.9% +/- 6.1%; P = 0.0078). Thirty-day mortality was 0%, and median survival time was 439 days. CONCLUSIONS: This study provides clear evidence that photodynamic therapy is effective in restoring biliary drainage and improving quality of life in patients with nonresectable disseminated cholangiocarcinomas Bismuth type III and IV. Compared with published data, survival time seems to be prolonged.
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Authors | M A Ortner, J Liebetruth, S Schreiber, M Hanft, U Wruck, V Fusco, J M Müller, H Hörtnagl, H Lochs |
Journal | Gastroenterology
(Gastroenterology)
Vol. 114
Issue 3
Pg. 536-42
(Mar 1998)
ISSN: 0016-5085 [Print] United States |
PMID | 9496944
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Bile Duct Neoplasms
(drug therapy)
- Bile Ducts, Intrahepatic
- Bilirubin
(blood)
- Cholangiocarcinoma
(drug therapy, psychology)
- Humans
- Length of Stay
- Photochemotherapy
(adverse effects)
- Quality of Life
- Stents
- Survival Rate
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