Applications of magnetic resonance spectroscopy to diagnosis and monitoring of mitochondrial disease.

Abstract

Magnetic resonance spectroscopy (MRS) can now be performed on routine high-field clinical magnetic resonance imaging systems. Over the last decade it has provided several useful insights into the pathophysiology of mitochondrial disorders. More recently, the feasibility of applications to clinical diagnosis and monitoring have been demonstrated. Exciting new work suggests that carefully supervised physical conditioning in conjunction with sodium dichloroacetate administration can markedly enhance both biochemical measures of aerobic metabolism and functional performance of patients with mitochondrial myopathies.

• Authors: P M Matthews, T Taivassalo
• Journal: Italian journal of neurological sciences (Ital J Neurol Sci) Vol. 18 Issue 6 Pg. 341-51 (Dec 1997) ISSN: 0392-0461 [Print] Italy
• PMID: 9494866 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Brain (metabolism)
• Clinical Trials as Topic
• Humans
• MELAS Syndrome (diagnosis, metabolism)
• Magnetic Resonance Spectroscopy
• Mitochondrial Myopathies (diagnosis, metabolism)
• Monitoring, Physiologic (methods)
• Muscles (metabolism)