[Pilot study of relapsed osteosarcoma and brain tumor with ifosfamide, carboplatin and etoposide (ICE therapy)].

Abstract

Ifosfamide, Carboplatin and Etoposide (ICE) therapy was used to treat 4 patients, 2 with refractory osteosarcoma, and one each with relapsed brain tumor and newly diagnosed brain tumor. ICE therapy was administered in doses of Ifosfamide 1,800 mg/m2 x 5, Carboplatin 400 mg/m2 x 2 and Etoposide 100 mg/m2 x 5. A total of 30 courses were administered. Two cases of osteosarcoma had a stable disease (range, 3-9 months) and 2 cases of brain tumor had a complete response by magnetic resonance imaging. Moderate or severe toxicity evaluated on a per course basis included: neutropenia 83%, thrombocytopenia 93%, fever 30%, hepatotoxicity 3%, and hemorrhagic cystitis 3%. The median time to hematologic recovery was 20 days. ICE therapy is highly effective for the treatment of refractory or recurrent solid tumors with acceptable toxicity.

• Authors: T Hirota, M Takeuchi, A Iwata, S Kitagawa, T Sato, K Konno, K Sawada, S Kobayashi, N Hamaguchi, H Agata, N Katano, T Fujimoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 25 Issue 3 Pg. 385-90 (Feb 1998) ISSN: 0385-0684 [Print] Japan
• PMID: 9492832 (Publication Type: English Abstract, Journal Article)

Chemical References

• Etoposide
• Carboplatin
• Ifosfamide

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bone Neoplasms (drug therapy, pathology)
• Brain Neoplasms (drug therapy)
• Carboplatin (administration & dosage, adverse effects)
• Child
• Drug Administration Schedule
• Etoposide (administration & dosage, adverse effects)
• Female
• Fever (chemically induced)
• Humans
• Ifosfamide (administration & dosage, adverse effects)
• Lung Neoplasms (secondary)
• Male
• Neoplasm Recurrence, Local (drug therapy)
• Neutropenia (chemically induced)
• Osteosarcoma (drug therapy, secondary)
• Pilot Projects
• Thrombocytopenia (chemically induced)