The change of periapical exudate prostaglandin E2 levels during root canal treatment.

Abstract

We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 +/- 54.1 pg/microliter in the first samples versus 48.4 +/- 37.9 pg/microliter in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.

• Authors: H Shimauchi, S Takayama, Y Miki, H Okada
• Journal: Journal of endodontics (J Endod) Vol. 23 Issue 12 Pg. 755-8 (Dec 1997) ISSN: 0099-2399 [Print] United States
• PMID: 9487853 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dinoprostone

Topics

• Dental Pulp Cavity
• Dinoprostone (analysis)
• Exudates and Transudates (chemistry)
• Humans
• Periapical Periodontitis (metabolism, therapy)
• Periapical Tissue (chemistry)
• Root Canal Therapy