[Successful therapy of persistent androgen-induced cholestasis with ursodeoxycholic acid].

Abstract

Drug-induced cholestasis can rarely persist for a considerable time period even after withdrawal of the drug. We report the case of a 55-year-old man with progressive jaundice after oral therapy with 17-alpha-methyltestosterone. Under empiric therapy with ursodeoxycholic acid the condition resolved completely. According to this observation, we suggest a therapeutic trial with ursodeoxycholic acid in cases of prolonged androgen-induced cholestasis.

• Authors: H Mörk, O al-Taie, O Klinge, M Scheurlen
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 35 Issue 12 Pg. 1087-91 (Dec 1997) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Erfolgreiche Therapie einer persistierenden androgeninduzierten Cholestase mit Ursodesoxycholsäure.
• PMID: 9487641 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cholagogues and Choleretics
• Testosterone Congeners
• Ursodeoxycholic Acid
• Methyltestosterone

Topics

• Cholagogues and Choleretics (therapeutic use)
• Cholestasis, Intrahepatic (chemically induced, drug therapy, pathology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Erectile Dysfunction (drug therapy, pathology)
• Humans
• Liver (pathology)
• Liver Function Tests
• Male
• Methyltestosterone (administration & dosage, adverse effects)
• Middle Aged
• Testosterone Congeners (administration & dosage, adverse effects)
• Ursodeoxycholic Acid (therapeutic use)