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A randomized double-blind clinical trial of the effect of amitriptyline on nocturnal masseteric motor activity (sleep bruxism).

Abstract
Using a double-blind and randomized experimental design, ten adult subjects with sleep bruxism were administered amitriptyline (25 mg/night) and placebo (25 mg/night), each compound over a period of one week. Neither the intensities and locations of pains nor the nocturnal masseteric electromyographic activities were significantly affected by the tricyclic antidepressant. In fact, intake of amitriptyline was unpredictably associated with either an increase or a decrease in masseteric electromyographic activity (microV.s/min of sleep). On the basis of this study, small doses of amitriptyline cannot be recommended for the control of sleep bruxism and associated discomforts.
AuthorsS E Mohamed, L V Christensen, J Penchas
JournalCranio : the journal of craniomandibular practice (Cranio) Vol. 15 Issue 4 Pg. 326-32 (Oct 1997) ISSN: 0886-9634 [Print] England
PMID9481995 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Amitriptyline
Topics
  • Adult
  • Amitriptyline (adverse effects, therapeutic use)
  • Antidepressive Agents, Tricyclic (adverse effects, therapeutic use)
  • Bruxism (drug therapy, physiopathology)
  • Double-Blind Method
  • Electromyography (drug effects, statistics & numerical data)
  • Female
  • Humans
  • Male
  • Masseter Muscle (drug effects, physiopathology)
  • Middle Aged
  • Sleep Wake Disorders (drug therapy, physiopathology)
  • Treatment Outcome

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