Abstract | BACKGROUND: OBJECTIVE: The study objective was to raise awareness of the cancer surveillance process in XP patients and the concerns involved in choice of therapy. METHODS: Since the spinal cord tumour was inoperable, the patient was treated with x-radiation, continued on isotretinoin treatment and was followed closely for tumour response. RESULTS: Despite sensitivity to sunlight, the patient had a normal acute response to the x-ray treatment without excessive skin reaction. Serial examinations by magnetic resonance imaging (MRI) starting 8 months after x-ray treatment was initiated, showed a marked gadolinium enhancement followed by regression. This clearing was first seen at 2 years after biopsy and persisted to at least 9 years after treatment. CONCLUSION: In contrast to the exaggerated sensitivity to UV radiation, XP patients may tolerate therapeutic doses of x-radiation. Isotretinoin treatment may have contributed to the good response of this spinal cord astrocytoma.
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Authors | J J DiGiovanna, N Patronas, D Katz, D Abangan, K H Kraemer |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
Vol. 2
Issue 3
Pg. 153-8
(Jan 1998)
ISSN: 1203-4754 [Print] United States |
PMID | 9479081
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Keratolytic Agents
- Isotretinoin
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Topics |
- Adult
- Astrocytoma
(complications, radiotherapy)
- Carcinoma, Basal Cell
(etiology, prevention & control)
- Carcinoma, Squamous Cell
(etiology, prevention & control)
- Humans
- Isotretinoin
(therapeutic use)
- Keratolytic Agents
(therapeutic use)
- Male
- Skin Neoplasms
(etiology, prevention & control)
- Spinal Cord Neoplasms
(complications, radiotherapy)
- Xeroderma Pigmentosum
(complications, drug therapy)
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