Perspectives on the use of microspectrophotometry in the diagnosis of pretumorous processes and malignant tumors.

Abstract

Comparative microspectrophotometric study of the nuclear Feulgen DNA content in pretumorous processes and cancers (larynx, endometrium, large intestine, and stomach) has made it possible to formulate an exponential law of DNA accumulation in cell populations in proliferating and malignant tissue. The dynamics of changes in the "index of DNA accumulation" can be used as an objective quantitative diagnostic test. A scale of malignant transformation was proposed with which the degree of probability of malignancy in pretumorous processes could be estimated. The data obtained allowed the author to propose a hypothesis of DNA superproduction as the basic cause of progressive neoplastic growth.

• Authors: G G Avtandilov
• Journal: Cancer (Cancer) Vol. 38 Issue 1 Pg. 254-8 (Jul 1976) ISSN: 0008-543X [Print] United States
• PMID: 947519 (Publication Type: Comparative Study, Journal Article)

Chemical References

• DNA

Topics

• Chromosomes (metabolism)
• DNA (analysis)
• Humans
• Hyperplasia (metabolism)
• Microchemistry
• Neoplasms (analysis, diagnosis)
• Precancerous Conditions (analysis, diagnosis)
• Spectrophotometry