Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: Most patients with ischemic stroke had high numbers of IL-8 mRNA expressing blood MNC, regardless of the time interval between onset of clinical symptoms and examination. There was a marked difference between patients with ischemic stroke and healthy subjects (median, 6228 versus 885 positive cells per 10(5) MNC; P<.0001). IL-8 levels in plasma correlated positively to IL-8 mRNA expression in examined patients (n=7) with ischemic stroke (r=.78, P<.05). In contrast, mRNA expression for the CC chemokines showed no significant difference between patients with ischemic stroke and healthy control subjects. CONCLUSIONS:
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Authors | N Kostulas, P Kivisäkk, Y Huang, D Matusevicius, V Kostulas, H Link |
Journal | Stroke
(Stroke)
Vol. 29
Issue 2
Pg. 462-6
(Feb 1998)
ISSN: 0039-2499 [Print] United States |
PMID | 9472890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokine CCL2
- Chemokine CCL3
- Chemokine CCL4
- Interleukin-8
- Macrophage Inflammatory Proteins
- RNA, Messenger
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Topics |
- Aged
- Aged, 80 and over
- Brain Ischemia
(blood, immunology)
- Chemokine CCL2
(biosynthesis, blood)
- Chemokine CCL3
- Chemokine CCL4
- Female
- Humans
- Interleukin-8
(biosynthesis, blood)
- Leukocytes, Mononuclear
(immunology)
- Macrophage Inflammatory Proteins
(biosynthesis, blood)
- Male
- Middle Aged
- RNA, Messenger
(biosynthesis)
- Reference Values
- Regression Analysis
- Transcription, Genetic
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