Maintenance therapy with itraconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome.

Abstract

We conducted a prospective, open trial to establish the efficacy of itraconazole 400 mg/d as maintenance treatment for cryptococcal meningitis in AIDS patients. Between February 1996 and May 1997, 50 patients were included for analysis. After a mean follow-up of 326 days, 2 of 38 patients (5.3 per cent) had relapses of symptomatic cryptococcal meningitis. Hepatotoxicity occurred in 2 cases. In conclusion, maintenance therapy with itraconazole 400 mg/d is effective in preventing recurrent cryptococcal meningitis.

• Authors: V Chotmongkol, W Sukeepaisarncharoen
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 80 Issue 12 Pg. 767-70 (Dec 1997) ISSN: 0125-2208 [Print] Thailand
• PMID: 9470329 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antifungal Agents
• Itraconazole

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Adult
• Antifungal Agents (therapeutic use)
• Female
• Humans
• Itraconazole (therapeutic use)
• Male
• Meningitis, Cryptococcal (drug therapy)
• Prospective Studies
• Recurrence