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Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin.

AbstractOBJECTIVE:
To determine side effect profiles and cure rates of azithromycin compared with erythromycin in the treatment of chlamydial cervicitis complicating pregnancy.
METHODS:
Pregnant patients with positive DNA antigen assays for Chlamydia trachomatis were randomized to either azithromycin, 1 g oral slurry in a single dose, or erythromycin, 500 mg every 6 hours for 7 days. Repeat assays were planned for 3 weeks after therapy. Side effects, compliance, and treatment efficacy were assessed.
RESULTS:
One hundred six women were enrolled, and eighty-five women completed the protocol. Significantly fewer gastrointestinal side effects were noted in the azithromycin group than in the erythromycin group (11.9% versus 58.1%, P < or = .01). Enhanced compliance was noted with azithromycin, because it was given in a single observed dose. Similar treatment efficacy was noted between azithromycin and erythromycin (88.1% versus 93.0%, P > .05).
CONCLUSION:
Compared with erythromycin, azithromycin is associated with significantly fewer gastrointestinal side effects in pregnancy. This association, along with the ease of administration and similar efficacy, suggests that azithromycin should be considered for the initial treatment of chlamydial cervicitis in pregnancy.
AuthorsC D Adair, M Gunter, T G Stovall, G McElroy, J C Veille, J M Ernest
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 91 Issue 2 Pg. 165-8 (Feb 1998) ISSN: 0029-7844 [Print] United States
PMID9469269 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Erythromycin
  • Azithromycin
Topics
  • Adult
  • Anti-Bacterial Agents (adverse effects, therapeutic use)
  • Azithromycin (adverse effects, therapeutic use)
  • Chlamydia Infections (drug therapy)
  • Chlamydia trachomatis
  • Erythromycin (adverse effects, therapeutic use)
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious (drug therapy)
  • Uterine Cervicitis (drug therapy)

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