Abstract |
The developmental change in the antiseizure effect of ifenprodil against pentylenetetrazole (PTZ) was examined in mice. Ifenprodil (i.p.) significantly increased the latency to seizure induced by PTZ in 7- and 10-day-old mice, but not in 14- or 21-day-old mice. Intracerebroventricular administration of ifenprodil also failed to modify the latency to PTZ-induced seizure in 21-day-old mice. Dizocilpine produced an increase in the latency to PTZ-induced seizure in 7- and 21-day-old mice. In an NMDA receptor binding assay using [3H]dizocilpine, ifenprodil was clearly more potent in inhibiting [3H]dizocilpine binding in a forebrain membrane preparation from 7- rather than 21-day-old mice. These results suggest that the remarkable antiseizure effect of ifenprodil against PTZ in 7-day-old mice may be related to the high proportion of ifenprodil-sensitive NMDA receptors in the brain.
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Authors | M Tsuda, T Suzuki, M Misawa |
Journal | Brain research. Developmental brain research
(Brain Res Dev Brain Res)
Vol. 104
Issue 1-2
Pg. 201-4
(Dec 19 1997)
ISSN: 0165-3806 [Print] Netherlands |
PMID | 9466723
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Convulsants
- Excitatory Amino Acid Antagonists
- Neuroprotective Agents
- Piperidines
- Dizocilpine Maleate
- ifenprodil
- Pentylenetetrazole
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Topics |
- Aging
(physiology)
- Animals
- Anticonvulsants
(therapeutic use)
- Convulsants
(antagonists & inhibitors)
- Dizocilpine Maleate
(pharmacology)
- Excitatory Amino Acid Antagonists
(therapeutic use)
- Injections, Intraventricular
- Male
- Mice
- Mice, Inbred Strains
- Neuroprotective Agents
(pharmacology)
- Pentylenetetrazole
(antagonists & inhibitors)
- Piperidines
(therapeutic use)
- Reaction Time
(drug effects)
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