Abstract | BACKGROUND: METHODS: In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months. The efficacy of therapy was evaluated monthly by the Intensity of Sexual Desire and Symptoms Scale and yearly by the Three Main Complaints questionnaire. RESULTS: All the men had a decrease in the number of deviant sexual fantasies and desires, from a mean (+/-SD) of 48+/-10 per week before therapy to zero during therapy (P<0.001), and a decrease in the number of incidents of abnormal sexual behavior (from 5+/-2 per month to zero, P<0.001) while receiving triptorelin. These effects were evident after 3 to 10 months of therapy (P<0.001) and persisted in all 24 men who continued therapy for at least 1 year. The men's mean serum testosterone concentration fell from 545+/-196 ng per deciliter (18.9+/-6.8 nmol per liter) before therapy to 23+/-14 ng per deciliter (0.8+/-0.5 nmol per liter, P<0.001) after 42 months of triptorelin. The main side effects were erectile failure, hot flashes, and decrease in bone mineral density in some men. CONCLUSIONS:
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Authors | A Rösler, E Witztum |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 338
Issue 7
Pg. 416-22
(Feb 12 1998)
ISSN: 0028-4793 [Print] United States |
PMID | 9459644
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Triptorelin Pamoate
- Gonadotropin-Releasing Hormone
- Testosterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adult
- Bone Density
(drug effects)
- Erectile Dysfunction
(chemically induced)
- Follicle Stimulating Hormone
(blood)
- Gonadotropin-Releasing Hormone
(agonists, analogs & derivatives)
- Humans
- Luteinizing Hormone
(blood)
- Male
- Paraphilic Disorders
(blood, drug therapy)
- Testis
(drug effects)
- Testosterone
(blood)
- Treatment Outcome
- Triptorelin Pamoate
(adverse effects, pharmacology, therapeutic use)
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