The effectiveness of intrauterine insemination in couples with sterility due to male infertility with and without a woman's hormone factor.

Abstract

OBJECTIVE:

To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor.

DESIGN:

Retrospective analysis.

SETTING:

Department of Gynecology and Obstetrics at the General Public Hospital, Horn, Austria.

PATIENT(S):

Seventy-eight long-standing involuntarily childless couples.

INTERVENTION(S):

After a follicular phase GnRH analog (buserelin) protocol with hMG stimulation of the woman and a Percoll gradient preparation and capacitation of the man's semen, an IUI was performed.

MAIN OUTCOME MEASURE(S):

Fecundity and baby-take-home rates.

RESULT(S):

One hundred nine inseminations were followed by 53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and 38 deliveries (34.9%; 95% CI 26.0%-44.6%). Forty-nine children were born and 47 are alive (43.1%).

CONCLUSION(S):

Intrauterine insemination combined with buserelin gonadotropin stimulation, Percoll semen preparation, and sperm capacitation is a feasible solution to the problem of sterility attributable to a male factor with and without a woman's hormone factor.

• Authors: E Rammer, F Friedrich
• Journal: Fertility and sterility (Fertil Steril) Vol. 69 Issue 1 Pg. 31-6 (Jan 1998) ISSN: 0015-0282 [Print] United States
• PMID: 9457928 (Publication Type: Journal Article)

Chemical References

• Menotropins
• Buserelin

Topics

• Adolescent
• Adult
• Birth Rate
• Buserelin (therapeutic use)
• Female
• Humans
• Infertility, Female (therapy)
• Infertility, Male (therapy)
• Insemination, Artificial, Homologous
• Male
• Menotropins (therapeutic use)
• Middle Aged
• Pregnancy
• Pregnancy Outcome
• Pregnancy Rate
• Retrospective Studies
• Sperm Capacitation (physiology)