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[Thymic and bronchial neuroendocrine tumors in multiple endocrine neoplasia type 1. GENEM1].

AbstractOBJECTIVES:
Multiple endocrine neoplasia type 1 (MEN 1) mainly affects parathyroid glands, pancreatic islets and pituitary gland. The aim of this study in 95 MEN 1 patients was to examine less frequent localizations thymic and bronchic neuroendocrine tumors (NET).
PATIENTS AND METHODS:
Two cases of bronchic NET were observed, both in women, and 4 cases of thymic NET, all in men, giving a prevalence of 7.3%. These NET were often asymptomatic. A metastatic diffusion was observed in 3 cases. Elevated plasma levels of glycoprotein hormone alpha subunit (SU) and FSH were observed in 3 and 1 cases respectively. Immunohistochemistry indicated the tumor cells to be frequently positively stained for HCG alpha and FSH.
DISCUSSION:
We conclude that all patients with MEN 1 should undergo screening for thoracic NET, especially in high risk familial subgroups and in case of elevated plasma alpha SU or FSH.
AuthorsA Murat, M F Heymann, S Bernat, B Dupas, A Y Delajartre, A Calender, P Despins, J L Michaud, S Giraud, M F Le Bodic, B Charbonnel
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 26 Issue 34 Pg. 1616-21 (Nov 08 1997) ISSN: 0755-4982 [Print] France
Vernacular TitleTumeurs neuro-endocrines thymiques et bronchiques au cours des néoplasies endocrines multiples de type 1. GENEM1.
PMID9452725 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Adult
  • Bronchial Neoplasms (diagnosis, immunology, physiopathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Multiple Endocrine Neoplasia Type 1 (immunology, physiopathology)
  • Prospective Studies
  • Retrospective Studies
  • Thymus Neoplasms (diagnosis, immunology, physiopathology)

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