Abstract |
We examined the effects of platelet-activating factor (PAF) on beta- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the beta- adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of beta- adrenoceptors in guinea pig lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of beta- adrenoceptors. These findings suggest that apafant may be effective in nonspecific airway hyperreactivity in asthma.
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Authors | Y Sugimoto, Y Nakayama, H Kishida, T Hayakawa, R Fujiwara, C Kamei |
Journal | Methods and findings in experimental and clinical pharmacology
(Methods Find Exp Clin Pharmacol)
Vol. 19
Issue 8
Pg. 547-52
(Oct 1997)
ISSN: 0379-0355 [Print] Spain |
PMID | 9442478
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Agonists
- Azepines
- Platelet Activating Factor
- Platelet Aggregation Inhibitors
- Receptors, Adrenergic, beta
- Triazoles
- WEB 2086
- Isoproterenol
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Topics |
- Adrenergic beta-Agonists
(pharmacology)
- Animals
- Azepines
(pharmacology)
- Binding, Competitive
- Bronchi
(drug effects, metabolism)
- Down-Regulation
(drug effects)
- Guinea Pigs
- Isoproterenol
(pharmacology)
- Male
- Muscle Relaxation
(drug effects)
- Muscle, Smooth
(drug effects)
- Platelet Activating Factor
(antagonists & inhibitors, pharmacology)
- Platelet Aggregation Inhibitors
(pharmacology)
- Receptors, Adrenergic, beta
(drug effects)
- Triazoles
(pharmacology)
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