HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of apafant on PAF-induced downregulation of beta-adrenoceptors in guinea pigs.

Abstract
We examined the effects of platelet-activating factor (PAF) on beta-adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the beta-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of beta-adrenoceptors in guinea pig lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of beta-adrenoceptors. These findings suggest that apafant may be effective in nonspecific airway hyperreactivity in asthma.
AuthorsY Sugimoto, Y Nakayama, H Kishida, T Hayakawa, R Fujiwara, C Kamei
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 19 Issue 8 Pg. 547-52 (Oct 1997) ISSN: 0379-0355 [Print] Spain
PMID9442478 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Agonists
  • Azepines
  • Platelet Activating Factor
  • Platelet Aggregation Inhibitors
  • Receptors, Adrenergic, beta
  • Triazoles
  • WEB 2086
  • Isoproterenol
Topics
  • Adrenergic beta-Agonists (pharmacology)
  • Animals
  • Azepines (pharmacology)
  • Binding, Competitive
  • Bronchi (drug effects, metabolism)
  • Down-Regulation (drug effects)
  • Guinea Pigs
  • Isoproterenol (pharmacology)
  • Male
  • Muscle Relaxation (drug effects)
  • Muscle, Smooth (drug effects)
  • Platelet Activating Factor (antagonists & inhibitors, pharmacology)
  • Platelet Aggregation Inhibitors (pharmacology)
  • Receptors, Adrenergic, beta (drug effects)
  • Triazoles (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: