Abstract |
Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system.
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Authors | A S Ghosh, J Ahamed, K K Chauhan, M Kundu |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 242
Issue 1
Pg. 54-6
(Jan 06 1998)
ISSN: 0006-291X [Print] United States |
PMID | 9439608
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ciprofloxacin
- Chloramphenicol
- DNA Gyrase
- DNA Topoisomerases, Type II
- Tetracycline
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Topics |
- Anti-Bacterial Agents
(metabolism)
- Anti-Infective Agents
(metabolism, pharmacology)
- Biological Transport
- Cell Membrane Permeability
- Chloramphenicol
(metabolism)
- Ciprofloxacin
(metabolism)
- DNA Gyrase
- DNA Topoisomerases, Type II
(genetics)
- Drug Resistance, Microbial
- Microbial Sensitivity Tests
- Shigella dysenteriae
(drug effects)
- Tetracycline
(metabolism)
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