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Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.

Abstract
Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system.
AuthorsA S Ghosh, J Ahamed, K K Chauhan, M Kundu
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 242 Issue 1 Pg. 54-6 (Jan 06 1998) ISSN: 0006-291X [Print] United States
PMID9439608 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Ciprofloxacin
  • Chloramphenicol
  • DNA Gyrase
  • DNA Topoisomerases, Type II
  • Tetracycline
Topics
  • Anti-Bacterial Agents (metabolism)
  • Anti-Infective Agents (metabolism, pharmacology)
  • Biological Transport
  • Cell Membrane Permeability
  • Chloramphenicol (metabolism)
  • Ciprofloxacin (metabolism)
  • DNA Gyrase
  • DNA Topoisomerases, Type II (genetics)
  • Drug Resistance, Microbial
  • Microbial Sensitivity Tests
  • Shigella dysenteriae (drug effects)
  • Tetracycline (metabolism)

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