Abstract | OBJECTIVE: METHOD: Sphincter of Oddi spasm was induced by prostigmine- morphine administration (0.5 mg prostigmine intramuscularly and 10 mg morphine subcutaneously) and visualized by quantitative hepatobiliary scintigraphy. The entire procedure was repeated during glyceryl trinitrate infusion (Nitrolingual 1 microg/kg/min for 120 min). RESULTS:
Prostigmine- morphine provocation caused significant increases in the time to peak activity (Tmax) over the hepatic hilum (HH: 34.33 +/- 5.05 vs. 22.77 +/- 3.26) and the common bile duct (CBD: 60.44 +/- 5.99 vs. 40.0 +/- 2.88) and in the half-time of excretion (T1/2) over the liver parenchyma (LP: 120.04 +/- 16.01 vs. 27.37 +/- 2.19), HH (117.61 +/- 14.71 vs. 31.85 +/- 3.99) and CBD (158.11 +/- 9.18 vs. 40.1 +/- 6.24), indicating a complete spasm at the level of the sphincter of Oddi. Glyceryl trinitrate infusion completely normalized the prostigmine- morphine-induced alterations in these quantitative parameters (TmaX over the LP: 11.33 +/- 1.13; over the HH: 18.88 +/- 1.48; and over the CBD: 36.22 +/- 1.92; and T1/2 over the LP: 28.21 +/- 1.83; over the HH: 33.42 +/- 3.10; and over the CBD: 41.66 +/- 6.33), suggesting an effective sphincter-relaxing effect of glyceryl trinitrate. CONCLUSION:
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Authors | B Velosy, L Madácsy, J Lonovics, L Csernay |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 9
Issue 11
Pg. 1109-12
(Nov 1997)
ISSN: 0954-691X [Print] England |
PMID | 9431903
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Opioid
- Cholinesterase Inhibitors
- Vasodilator Agents
- Neostigmine
- Morphine
- Aspartate Aminotransferases
- Nitroglycerin
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Topics |
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage)
- Aspartate Aminotransferases
(analysis)
- Biliary Tract
(diagnostic imaging, physiology)
- Cholinesterase Inhibitors
(administration & dosage)
- Female
- Humans
- Injections, Intramuscular
- Injections, Subcutaneous
- Middle Aged
- Morphine
(administration & dosage)
- Neostigmine
(administration & dosage)
- Nitroglycerin
(pharmacology)
- Radionuclide Imaging
- Spasm
(chemically induced, drug therapy)
- Sphincter of Oddi
(diagnostic imaging, drug effects)
- Vasodilator Agents
(pharmacology)
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