Abstract | BACKGROUND: METHODS: Ninety patients with uncomplicated AMI (age range 39-75 years, median 61 years) were assigned randomly to six groups of 15 patients each. They were treated with placebo or one of the following ACE inhibitors for 30 days: captopril, cilazapril, enalapril, lisinopril or quinapril. HRV was assessed 3 days after the onset of AMI (baseline), and 30 days after treatment. Fifteen patients with stable coronary artery disease and 15 healthy volunteers, age- and sex-matched with AMI patients, served as controls. RESULTS: At baseline, time and frequency domain HRV indices in the AMI groups were equally less than those in patients with stable coronary artery disease and normal volunteers. Compared with placebo, quinapril, lisinopril and captopril changed frequency domain HRV indices 30 days after initiation of treatment, indicating an increase in vagal tone, whereas enalapril and cilazapril had no significant effect on these indices. Most of the time domain HRV indices 30 days after initiation of treatment increased significantly in all patients treated with ACE inhibitors, but remained unchanged in the placebo group. Frequency domain and time domain HRV indices 30 days after treatment in the quinapril group did not differ statistically from those in patients with stable coronary artery disease, but were less than those in normal volunteers. CONCLUSIONS:
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Authors | A G Kontopoulos, V G Athyros, A A Papageorgiou, V M Skeberis, E C Basayiannis, H Boudoulas |
Journal | Coronary artery disease
(Coron Artery Dis)
1997 Aug-Sep
Vol. 8
Issue 8-9
Pg. 517-24
ISSN: 0954-6928 [Print] England |
PMID | 9431480
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Isoquinolines
- Tetrahydroisoquinolines
- Cilazapril
- Enalapril
- Captopril
- Lisinopril
- Quinapril
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Topics |
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology, therapeutic use)
- Arrhythmias, Cardiac
(prevention & control)
- Blood Pressure
(drug effects)
- Captopril
(therapeutic use)
- Cilazapril
(therapeutic use)
- Death, Sudden, Cardiac
(prevention & control)
- Electrocardiography
- Enalapril
(therapeutic use)
- Female
- Fourier Analysis
- Heart Rate
(drug effects)
- Humans
- Isoquinolines
(therapeutic use)
- Lisinopril
(therapeutic use)
- Male
- Middle Aged
- Myocardial Infarction
(diagnosis, drug therapy)
- Prospective Studies
- Quinapril
- Single-Blind Method
- Statistics, Nonparametric
- Stroke Volume
(drug effects)
- Tetrahydroisoquinolines
- Treatment Outcome
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