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Spinal cord compression by heterotopic ossification associated with pseudohypoparathyroidism.

Abstract
This report describes a 37-year-old man presenting with a gait disturbance due to spastic paraparesis. Physical findings showed typical features of Albright's hereditary osteodystrophy, including short stature, obesity, brachydactyly and dental hypoplasia. He was diagnosed as having pseudohypoparathyroidism type Ia, on the basis of his hypocalcaemia, hyperphosphataemia, increased plasma level of parathyroid hormone (PTH), and the unresponsiveness to exogenous PTH loading of his urinary excretion of both nephrogenous cyclic adenosine monophosphate and phosphate. Magnetic resonance imaging and myelographic computed tomographic scans clearly demonstrated severe compression of the spinal cord at T 9/10 by tumour-like ossifications of the paravertebral ligaments. Neurosurgical decompression therapy was, therefore, performed to alleviate his spastic paraparesis. This was a rare case of pseudohypoparathyroidism complicated with spinal cord compression caused by ectopic ossification of the ligaments.
AuthorsY Yamamoto, Y Noto, M Saito, H Ichizen, H Kida
JournalThe Journal of international medical research (J Int Med Res) 1997 Nov-Dec Vol. 25 Issue 6 Pg. 364-8 ISSN: 0300-0605 [Print] England
PMID9427170 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Parathyroid Hormone
  • Phosphates
  • Cyclic AMP
  • Calcium
Topics
  • Adult
  • Calcium (blood)
  • Cyclic AMP (urine)
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Ossification, Heterotopic (complications, diagnosis)
  • Paraparesis, Tropical Spastic (complications)
  • Parathyroid Hormone (blood)
  • Phosphates (blood, urine)
  • Pseudohypoparathyroidism (complications, diagnosis)
  • Spinal Cord Compression (complications, diagnosis)
  • Tomography, X-Ray Computed

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