Abstract |
The in-vitro activity of AM-1155, a 6-fluoro-8-methoxy quinolone, was compared with those of temafloxacin, sparfloxacin, tosufloxacin, ciprofloxacin, ofloxacin and cefmetazole, a cephamycin, against a variety of anaerobic bacteria. Although AM-1155 demonstrated only modest activity against the Bacteroides fragilis group and Prevotella bivia (MIC90s > or =3.13 mg/mL), 76% of the B. fragilis strains tested were inhibited at AM-1155 concentrations of 0.78 mg/L. AM-1155 was highly active against Prevotella intermedia, Porphyromonas gingivalis, Fusobacterium spp., Clostridium perfringens and Mobiluncus spp. (MIC90s < or =0.39 mg/L). An in-vivo study using a mixed infection with AM-1155- and tosufloxacin-susceptible B. fragilis and Escherichia coli strains in rat granuloma pouch was performed. AM-1155 was effective against both organisms whereas tosufloxacin was effective only against E. coli. These results correlated well to the higher pouch levels of AM-1155 than those of tosufloxacin. Clostridium difficile overgrowth was found in the caecum of mice treated with ampicillin both 1 and 7 days after 5 days dosing, but not in AM-1155-treated mice. These results suggest that the clinical efficacy of AM-1155 against infections involving most anaerobic bacteria except for the B. fragilis group and P. bivia should be evaluated further.
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Authors | N Kato, H Kato, K Tanaka-Bandoh, K Watanabe, K Ueno |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 40
Issue 5
Pg. 631-7
(Nov 1997)
ISSN: 0305-7453 [Print] England |
PMID | 9421310
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Fluoroquinolones
- Piperazines
- Quinolones
- Gatifloxacin
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Topics |
- Animals
- Anti-Infective Agents
(pharmacology)
- Bacteria, Anaerobic
(drug effects)
- Bacterial Infections
(drug therapy, microbiology)
- Cecum
(microbiology)
- Fluoroquinolones
- Gatifloxacin
- Granuloma
(microbiology)
- Mice
- Mice, Inbred Strains
- Microbial Sensitivity Tests
- Piperazines
(pharmacology)
- Quinolones
(pharmacology)
- Rats
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