Antiamoebic activity of 3,3'-fluro-4,4'-di-(pyrrolidine-2-ylidene amino)-diphenyl (liroldine), against experimentally infected intestinal and hepatic amoebiasis.

Abstract	HL 707, Liroldine, a novel synthetic compound, was found effective against both extraintestinal and intestinal amoebiasis in animal models. Its activity against hepatic infection in golden hamsters is comparable with that of different derivatives of nitroimidazoles used for human treatment. Against intestinal amoebiasis in Wistar rats, the activity was superior to nitroimidazoles and chloroquine. Paramomycin was comparable and diloxanide furoate was marginally superior. The comparative in vitro and in vivo studies with standard marketed drugs and Liroldine indicate an excellent profile of the compound against experimental amoebiasis. LD50 of Liroldine determined in mice is 910 mg/kg x 1, po and 940 mg/kg x 1 ip).
Authors	D K Chatterjee, S N Iyer, B Venugopalan, W Raether
Journal	Indian journal of experimental biology (Indian J Exp Biol) Vol. 35 Issue 7 Pg. 765-770 (Jul 1997) ISSN: 0019-5189 [Print] India
PMID	9418378 (Publication Type: Journal Article)
Chemical References	Amebicides Biphenyl Compounds Pyrrolidines liroldine
Topics	Amebiasis (drug therapy) Amebicides (therapeutic use) Animals Biphenyl Compounds (therapeutic use) Cricetinae Humans Intestinal Diseases, Parasitic (drug therapy) Liver Diseases, Parasitic (drug therapy) Mesocricetus Mice Microbial Sensitivity Tests Pyrrolidines (therapeutic use) Rats Rats, Wistar

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