Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study.

Abstract

The active form of vitamin B12 (methylcobalamin) has been reported to be effective on sleep-wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B12 has not been properly evaluated. The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13-55 years (26.8 +/- 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep-log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.

• Authors: M Okawa, K Takahashi, K Egashira, H Furuta, Y Higashitani, T Higuchi, H Ichikawa, Y Ichimaru, Y Inoue, Y Ishizuka, N Ito, K Kamei, M Kaneko, Y Kim, M Kohsaka, T Komori, T Kotorii, M Matsumoto, K Mishima, Y Mizuki, K Morimoto, H Nagayama, T Ohta, N Okamoto, S Takahashi
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 51 Issue 5 Pg. 275-9 (Oct 1997) ISSN: 1323-1316 [Print] Australia
• PMID: 9413873 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Vitamin B 12

Topics

• Adolescent
• Adult
• Aged
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Sleep Wake Disorders (drug therapy, psychology)
• Vitamin B 12 (blood, therapeutic use)