Cultured allogeneic keratinocyte sheets accelerate healing compared to Op-site treatment of donor sites in burns.

Abstract

Donor site treatment is a crucial issue in the treatment of extensive burns. In this single-blind, randomized study treatment of donor sites with a polyurethane dressing, Op-Site (Smith & Nephew, York, U.K.) is compared to treatment with allogeneic cultured keratinocyte sheets. Results show a mean healing time of 6.7 days with use of cultured keratinocyte sheets compared to mean healing time of 13.6 days with Op-Site treatment. Also, improvement in the comfort of patients as the result of less exudate formation and pain attenuation was noted.

• Authors: L A Duinslaeger, G Verbeken, S Vanhalle, A Vanderkelen
• Journal: The Journal of burn care & rehabilitation (J Burn Care Rehabil) 1997 Nov-Dec Vol. 18 Issue 6 Pg. 545-51 ISSN: 0273-8481 [Print] United States
• PMID: 9404990 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Polyurethanes

Topics

• Adolescent
• Adult
• Aged
• Burns (therapy)
• Child
• Child, Preschool
• Female
• Humans
• Keratinocytes (physiology)
• Male
• Middle Aged
• Occlusive Dressings
• Pain (prevention & control)
• Polyurethanes (therapeutic use)
• Prospective Studies
• Skin Transplantation (methods)
• Transplantation, Homologous
• Treatment Outcome
• Wound Healing