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End-stage cystic fibrosis: improved diabetes control 2 years after successful isolated pancreatic cell and double-lung transplantation.

Abstract
Over a period of years, insulin-dependent diabetes and respiratory insufficiency developed in a 35-year-old patient with end-stage cystic fibrosis. After waiting more than 4 years while receiving maintenance treatment with continuous liquid O2 and nasal ventilation, the patient underwent double-lung and pancreatic islet cell transplantation. Subsequently, the patient has enjoyed a normal life with full employment and much better control of his diabetes. Pancreatic islet cell transplantation is a simple and innocuous technique easily added to the end of lung transplantation. These new pancreatic cells, although locally injected, are still secreting more than 2 years later as assessed by repeated C-peptide measurements.
AuthorsJ M Tschopp, M H Brutsche, J G Frey, A Spiliopoulos, L Nicod, T Rochat, P Morel
JournalChest (Chest) Vol. 112 Issue 6 Pg. 1685-7 (Dec 1997) ISSN: 0012-3692 [Print] United States
PMID9404774 (Publication Type: Case Reports, Journal Article, Review)
Topics
  • Acute Disease
  • Adult
  • Combined Modality Therapy
  • Cystic Fibrosis (surgery)
  • Diabetes Mellitus, Type 1 (surgery)
  • Follow-Up Studies
  • Humans
  • Islets of Langerhans Transplantation
  • Lung Transplantation
  • Male
  • Remission Induction
  • Respiratory Insufficiency (surgery)
  • Time Factors

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