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Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal.

Abstract
Administration of a bolus dose of mCPP, a 5-HT2C receptor agonist, to rats provokes endocrine and behavioural effects that are reminiscent of some of the symptoms of human depression. Rats exposed to chronic mild stress (which is also a key factor in the precipitation of human depression) were hypersensitive to mCPP, whilst chronic treatment with antidepressant serotonin re-uptake inhibitors suppressed the responsiveness to mCPP. Similarities also exist with respect to withdrawal reactions following chronic alcohol or benzodiazepine abuse. In humans, a bolus dose of mCPP can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-HT2C receptor hyperresponsiveness in these conditions also. It is hypothesized that chronic treatment with SSRI's can prevent migraine attacks and drug craving.
AuthorsH O Kalkman
JournalInternational journal of clinical pharmacology research (Int J Clin Pharmacol Res) Vol. 17 Issue 2-3 Pg. 75-7 ( 1997) ISSN: 0251-1649 [Print] Switzerland
PMID9403358 (Publication Type: Journal Article, Review)
Chemical References
  • Piperazines
  • Serotonin Receptor Agonists
  • 1-(3-chlorophenyl)piperazine
Topics
  • Animals
  • Depression (physiopathology)
  • Humans
  • Migraine Disorders (physiopathology)
  • Piperazines (pharmacology)
  • Rats
  • Serotonin Receptor Agonists (pharmacology)
  • Species Specificity
  • Substance Withdrawal Syndrome (physiopathology)

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