Abstract |
Administration of a bolus dose of mCPP, a 5-HT2C receptor agonist, to rats provokes endocrine and behavioural effects that are reminiscent of some of the symptoms of human depression. Rats exposed to chronic mild stress (which is also a key factor in the precipitation of human depression) were hypersensitive to mCPP, whilst chronic treatment with antidepressant serotonin re-uptake inhibitors suppressed the responsiveness to mCPP. Similarities also exist with respect to withdrawal reactions following chronic alcohol or benzodiazepine abuse. In humans, a bolus dose of mCPP can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-HT2C receptor hyperresponsiveness in these conditions also. It is hypothesized that chronic treatment with SSRI's can prevent migraine attacks and drug craving.
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Authors | H O Kalkman |
Journal | International journal of clinical pharmacology research
(Int J Clin Pharmacol Res)
Vol. 17
Issue 2-3
Pg. 75-7
( 1997)
ISSN: 0251-1649 [Print] Switzerland |
PMID | 9403358
(Publication Type: Journal Article, Review)
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Chemical References |
- Piperazines
- Serotonin Receptor Agonists
- 1-(3-chlorophenyl)piperazine
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Topics |
- Animals
- Depression
(physiopathology)
- Humans
- Migraine Disorders
(physiopathology)
- Piperazines
(pharmacology)
- Rats
- Serotonin Receptor Agonists
(pharmacology)
- Species Specificity
- Substance Withdrawal Syndrome
(physiopathology)
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